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Some start with semaglutide given its lower price and excellent results, then switch to tirzepatide if they plateau or want to maximize outcomes

Patients seeking GLP-1 therapy should rely on FDA-approved medications with established efficacy profiles, including landmark trials like STEP (semaglutide) demonstrating approximately 15% body weight reduction and SCALE (liraglutide) showing 5-8% weight reduction, along with improved glycemic control in patients with diabetes

Comprehensive Clinical support GLP-1s are only considered within the context of whole-person care

Even patients who understand the importance of rotation may inadvertently favour certain areas due to convenience or habit