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169 It has been demonstrated that the expression of human Z AAT protein in mouse liver leads to elevated oxidative stress and lowered antioxidant protection

Effective timing: For IDRs initiated on or after January 1, 2026, applicable fees (CMS administrative and/or arbitration fees) will be billed quarterly, beginning with May 2026 invoices under Additional Items. Bradford Regional Medical Center Closing Facility closure details: Bradford Regional Medical Centers 20bed inpatient unit and emergency department will close on May 17, 2026 , following acquisition of the campus by LECOM