GLP-1 Medications and IBS Symptom Overlap Common side effects of GLP-1 therapynausea, constipation, diarrhea, and abdominal discomfortcan mimic or worsen existing IBS symptoms, making it difficult to distinguish between medication effects and disease activity
In mice single-cell RNA sequencing identified a subpopulation of GLP-1R-positive memory T-cells that was mainly composed of exhausted CD8+ T cells: functionally, stimulation of the GLP-1R on these cells was found to mediate apoptosis and anergic signals, thereby suppressing effector T-cell function and the inflammatory response ( 3.2 Intestinal mucosal barrier IELs are a heterogeneous population of T cells located among intestinal epithelial cells (IECs), where they contribute to maintaining mucosal barrier integrity (59, 60)
Separate from GLP-1 mechanism combines with Mounjaro, Ozempic, Biopatid, Retatrutide
The move could significantly expand access to these treatments for people with diabetes and obesity
