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The diversity of circulating mediators suggests dynamic cross-talk among them, potentially leading to mutual stimulation or inhibition [61,64,67,119]

These data should therefore be interpreted as hypothesis-generating, with the randomized no-heterogeneity findings providing the firmer basis for combining the classes

Per il lettore italiano conta soprattutto il dato europeo: il 18 agosto 2025 la Commissione europea ha concesso a resmetirom (Rezdiffra) un autorizzazione condizionata valida in tutta lUnione , per gli adulti con MASH non cirrotica e fibrosi moderata-avanzata