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D., Kreider J

Once gout has been diagnosed, conventional medical treatments include: Drugs for acute attacks (non-steroidal anti-inflammatory drugs [NSAIDs], corticosteroids, colchicine) Drugs to reduce hyperuricemia (xanthine oxidase inhibitors like allopurinol to decrease production of uric acid, uricosuric drugs to increase excretion of uric acid) Emerging Therapeutics Most mammals are able to convert uric acid to allantoin with the enzyme uricase and then easily excrete it through the kidneys

The rationale: early-phase neuroplasticity benefits from sustained HGF/c-Met signaling, but once synaptic remodeling is initiated, daily pulses are sufficient to maintain the effect

Oral tablets absorb only 1 to 2% at high doses through passive absorption