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Useful Resources Treatment of malar (under eye bags) Reduction of pockets of body fat such as the abdomen and arms Paradoxical Adipose Hypertrophy (PAH)
The summaries were compiled in both narrative and tabulated formats and circulated to the expert panel for review
They added GHK-Cu in concentrations of 10 M to 10 M and measured: Collagen synthesis (by radioactive proline incorporation) Non-collagen protein synthesis Cell proliferation What they found: Stimulation of collagen synthesis by 70 % at the optimal concentration of 10 M (1 nM) The effect was NOT dependent on increased proliferation, fibroblasts increased production per cell Background: GHK without copper had a dramatically weaker effect , Cu is critical Reversibility: After removing GHK-Cu, synthesis returned to baseline Why it matters: This is the fundamental mechanistic study that documented the effect of GHK-Cu on collagen
Copper ions delivered by GHK-Cu also demonstrate up to 90% inhibition of type 1 5-alpha reductase at specific concentrations
