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Eligibility is determined through medical evaluation

These macrophages secrete high levels of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which propagate inflammation and damage to the vascular endothelium ( Accumulation of uremic toxins in CKD contributes to macrophage activation

The total activity score is made up of: The degree of redness (03) and scale (02) Mucous membrane involvement (01) Recent hair loss (01), nonscarring alopecia (03) Total damage score is made up of: The degree of dyspigmentation (02), and scarring (02) Persistence of dyspigmentation more than 12 months doubles the dyspigmentation score Scalp scarring (0,3,4,5,6) Biopsy findings Patients with SLE often undergo skin biopsy

However, hepatic failure and the development of chronic liver disease in this setting is exceedingly rare