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Because of the life-threatening metabolic disturbances (acidosis and ketosis) that are associated with IEMs, an entire field of preconception and postnatal screening has arisen

Aetna has reached these conclusions based upon a review of currently available clinical information (including clinical outcome studies in the peer-reviewed published medical literature, regulatory status of the technology, evidence-based guidelines of public health and health research agencies, evidence-based guidelines and positions of leading national health professional organizations, views of physicians practicing in relevant clinical areas, and other relevant factors)