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An intradermal test dose is recommended before cyanocobalamin injection is administered to patients suspected of being sensitive to this drug

2.5.2 The Keap1-NRF2 pathway mediates ferroptosis The NRF2 transcription factor stimulates the production of NADPH by blocking the expression of antioxidant genes and increasing the expression of enzymes in the pentose phosphate pathway, which decreases the sensitivity of cells to ferroptosis (85)