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C9ORF72: what it is, what it does, and why it matters

Clin Chim Acta 1985, 145: 69-76

Methionine or cysteine (0.5%) added to the diet can overcome the severe methionine deficiency induced in rats by the addition of 1% acetaminophen, (an equivalent to the 4 gm/day to a human dose) [12]

In particular this means avoiding prolonged periods of conservative management of change in the nail or periungual tissues that are limited to one digit and do not respond promptly to appropriate treatment