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Early trials showed promise, but severe nausea and a relatively long onset time limited its clinical value

Appetite Suppressants: Stimulators of anorexigenic pathway Leptin Leptin treatment has proved to be ineffective for attaining weight reduction in obese individuals

A double-blind, placebo-controlled trial in 90 HIV-positive patients with symptomatic distal symmetrical polyneuropathy found no benefit of intramuscular injection with 1 g/day of ALCAR for two weeks in the intention-to-treat analysis, but there was some pain relief in the group of 66 patients who completed the trial (84)

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