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So far, bariatric surgery has proven to be the most effective approach to body weight (BW) reduction, as a recent network meta-analysis demonstrated that it was associated with a 17.7% greater BW loss compared to lifestyle intervention/medical therapy 6 , with substantial improvements or remission of T2D, dyslipidemia and hypertension 7

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P53 mutations are highly prevalent in breast tumors [197] potentially granting a survival advantage to breast cancer cells as they navigate mechanically challenging microenvironments