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Activation of Nrf2 leads to the upregulation of various antioxidant and detoxifying enzymes, enhancing the cellular defense against oxidative damage [213]

The primary components of this system include: The Sinoatrial (SA) Node : Known as the hearts natural pacemaker, the SA node generates electrical impulses that set the hearts rhythm

Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death