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Opioid and DA receptors modulate HPA function [79], for example, MOR is highly expressed in the pituitary [40]

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Apoptosis was mediated by reactive oxygen species (ROS) in cancer cells due to increased oxidative stress, altered mitochondrial membrane permeability (MMP) and inhibition of antioxidant enzymes (superoxide dismutase and glutathione reductase) caused by compounds 65 and 66

Only VCTE measurements based on at least 10 valid shots and success rates 60% were considered reliable and were used for statistical analysis