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Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH

10.1056/NEJMoa003417 85 von ScholtenB

Even as more and more competitors flood the increasingly crowded obesity space, Amgen believes that its investigational antibody-peptide therapy MariTide can carve out a unique position on the market by offering a more convenient dosing schedulewithout sacrificing efficacy