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Additionally, obesity itself increases abdominal pressure and weakens the lower esophageal sphincter (LES), the muscle that prevents acid backflowso initial weeks of rapid weight loss may temporarily worsen reflux before digestive physiology normalizes

Overall, adverse effects account for approximately a 10% discontinuation rate of the medication

Some research suggests these medications may cause mild vasodilation and potentially reduce systemic vascular resistance, which could trigger a compensatory increase in heart rate to maintain cardiac output and blood pressure

Seasonal differences in aggression and site tenacity in male green frogs, Rana clamitans