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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

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Our results are consistent with previously reported changes in targeted-metabolite levels (butyrates, carnitines, BCAAs, citrate, uridine, and urate) 2,16,20,27 , which in turn, validate the protocol used here