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Some embodiments provide medicaments, supplements, nutraceuticals, functional foods (e.g., any fresh or processed food that claims health promoting and/or disease preventing properties that exceed the basic nutritional functions of providing nutrients), pharmaceuticals, Over The Counter (OTC) products, oral care products, cosmetics such as sweet lipstick, and other personal care products, including one or more of compounds 101-105 or cooling compositions described herein

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Mediation analysis confirmed that reduction in inflammatory biomarkers was a contributing pathway to cardiovascular protection

As the kidneys receive ~ 25% of the cardiac output, a condition known as cardiorenal syndrome (CRS) can manifest when either the heart or the kidneys fail (Ronco et al