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identified the first potent inhibitors of human SQOR ( 50 value of 29 nM with suitable physicochemical properties and good cell permeability (Figure 10) ( 50 values for the respiratory complexes I, II, and III, dihydroorotate dehydrogenase, and electron transferring flavoprotein:ubiquinone oxidoreductase were all at least 1,000-fold higher than the IC 50 for SQOR ( 50 , of 56 M) and in neonatal rat ventricular cardiomyocytes (CC 50 of 26 M)