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Compression of the L5 nerve root causes pain radiating from the buttock down the lateral leg to the top of the foot, with potential weakness in foot dorsiflexion

Studies show SGLT2 Inhibitors may have the following benefits: Shown to extend lifespan in mice May reduce inflammation and oxidative stress May lower HbA1c May improve cardiovascular health and kidney health May lower the risk of dementia and Parkinsons May eliminate senescent cells May encourage moderate weight loss Though both Invokana (Canagliflozin) and Brenzavvy (Bexagliflozin) work in the same way, Invokana has more years of research supporting its potential benefits, while Brenzavvy is a relatively new SGLT2 that may show similar longevity benefits

RA patients with a personal or family history of pancreatitis require additional screening before starting therapy