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(11) Their findings suggest an upward shift in IGF-1 from baseline values around 160 ng/mL to roughly 250265 ng/mL, which corresponds to an apparent 1.6-fold increase

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Interestingly, the GLP-1 receptor agonist, dulaglutide, and the dual GLP-1 and GIP receptor agonist, tirzepatide, are both characterized by a strong delayed gastric emptying upon a single dose administration, but the effect tends to subside as gastric emptying tachyphylaxis is observed after several weeks of treatment