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Unfortunately, a phase II clinical trial of UBX0101 (NCT03513016) was completed in patients with osteoarthritis and the promising results observed (Table 1), in vitro and in vivo, have not been up to the expectations in treated patients, leading only to a decrease of pain, without a significant improvement of the disease 30

This hypothesis is supported by elevations in brain HGF levels measured in several degenerative diseases including amyotrophic lateral sclerosis, multiple sclerosis, Parkinsons disease, spinal cord injury and AD [78-82]

This allows the monitoring of BBB permeability over time, which is useful for evaluating the course of the disease or the effectiveness of treatment (Law et al., 2004

Practice Committee of the American Society for Reproductive Medicine