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and insulin sensitizers (metformin, pioglitazone) may partially offset GH-driven insulin resistance and are worth maintaining in co-diagnosed hepatogenous diabetes

Researchers surmise that CJC-1295, as a derivative of GHRH, may offer the same benefits by mimicking the dual neuronal and endocrine function of hypothalamic GHRH activity [8, 9]

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Melatonin itself has been studied for sleep, circadian rhythm regulation, and broader immunologic and antioxidant effects, although the clinical benefits are not uniformly dramatic in every elderly population