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Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)

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There has not been much research into why these medications can result in hair loss, but they are thought to trigger the resting phase for follicles, leading to hair being pulled out more easily, and a thinning appearance

To reach therapeutic levels, functional medicine practitioners often recommend taking 2 to 4 capsules daily, strictly divided into multiple doses