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(2025, May 29)
Retatrutide data currently consists of impressive surrogate endpoint improvements, while hard endpoint data awaits future trials
For example, with semaglutide (Ozempic), the recommended titration schedule for type 2 diabetes involves starting with a 0.25 mg dose once weekly for four weeks, followed by an increase to 0.5 mg once weekly for at least four weeks
One notable real world example comes from the digital weight loss clinic Embla, where patients achieved an average 14.8% weight loss at 64 weeks using a maximum mean semaglutide dose of 0.77 mg, about 36% of the standard cumulative dose, while maintaining effectiveness
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