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project number 390874280 and DFG support LA 3680/91 and 101) (N.L.)

POTENTIAL MECHANISMS UNDERLYING THE DECLINE IN GH SECRETION WITH AGE Three hypothalamic factors regulate GH secretion: somatostatin (Somatotropin Release-Inhibiting Factor, SRIF), growth hormone-releasing hormone (GHRH), and ghrelin (11) (Figure 2)

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After being stimulated by GLP-1 or various agonists, GLP-1R in pancreatic cells internalizes and is eventually recycled back to the cell surface