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In an in vitro study, tirzepatide elicited a cAMP response in a human pancreatic -cell line that was significantly higher than that observed for either GLP-1 or GIP alone, indicating a synergistic or additive activation of signaling in pancreatic -cells by GIP and GLP-1 (63)

This triple-agonist approach has shown incredible promise in clinical trials, with participants experiencing significant reductions in body weight and improved insulin sensitivity

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