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Debido a que la fosfatidilcolina es necesaria para la sntesis de partculas de lipoprotenas de muy baja densidad (VLDL) (ver Funcin), la deficiencia de colina produce una secrecin alterada de VLDL y acumulacin de grasa en el hgado (esteatosis), lo que en ltima instancia conduce a dao heptico

This is reflected in the high rates of irritability reported in community and clinical youth samples with depression, varying between 30 and 85% 3,4,5