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Research has linked prolonged PPI use to: Nutrient deficiencies (magnesium, calcium, iron, vitamin B12) (5) Increased risk of bone fractures and osteoporosis (6) Gut dysbiosis and increased risk of SIBO (7) Low stomach acid (which has been associated with leaky gut and autoimmune conditions) Higher susceptibility to infections Potential kidney and cardiovascular concerns (8, 9) Increased risk of cancer (10) Increased risk of inflammatory bowel disease (IBD) And, of course, PPIs do not address the root cause of reflux

This hepatic enzyme converts UA to allantoin, and its absence results in serum UA concentrations relatively elevated by, typically, an order of magnitude

PMID 6420106

General subcutaneous injection guidance usually points to the abdomen, outer thigh, and upper arm