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20 Several mechanisms have been proposed to contribute to the benefits of SGLT-2 inhibitors, which are seen as a class effect across many of those currently on the market in Australia and other countries

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Visfatin promotes monocyte adhesion by upregulating ICAM-1 and VCAM-1 expression in endothelial cells via activation of p38-PI3K-Akt signaling and subsequent ROS production and IKK/NF-kappaB activation