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Nirmaladevi, D

Subsequent work by Sun and colleagues in the APP/PS1 mouse model identified downstream PI3K/AKT pathway activation as a major component of the mechanism, with the PI3K inhibitor wortmannin reversing Dihexas anti-inflammatory and anti-apoptotic effects [5]

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The decline was driven by two things happening at once: the cells themselves ageing, and the mechanical environment around them deteriorating as collagen fibres fragment (PMID: 16723701)