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Glucagon-like peptide-1 and glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes

Functional medicine adds diet, lifestyle, nutrients, and targeted medications to address the root causes

An updated systematic review and network meta-analysis of GLP-1 receptor agonists and polyagonists ranked retatrutide at or near the top for weight loss among the modern agents, while also flagging that the strongest-effect agents tend to carry the highest adverse-event burden

GLP-1 receptor agonists have reshaped how clinicians and researchers think about metabolic disease, revealing a hormone system that links appetite, reward, emotion, inflammation and cardiovascular health