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Taken as a once-weekly injection Doses studied so far include: 1 mg, 4 mg, 8 mg, and up to 12 mg Gradual dose increases are used to help the body adjust and reduce side effects Because retatrutide is still in development, the exact dosing schedule could change before it becomes available, but the general approach is expected to feel similar to current GLP-1 medications

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Its co-secreted with insulin in response to nutrient intake and forms part of a broader network of hormones involved in metabolic signaling

In fact, major clinical trials like the SURMOUNT-1 study showed that tirzepatide led to substantial and sustained weight reduction in participants