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The conclusions from these essentially negative MR findings have, however, been questioned in a well-argued critique 31 , pointing out the limitations of genetic markers that explain only a small component (i.e., 7.7% at most 5 ) of serum UA variance and querying whether the core assumptions of MR, including the absence of confounds as well as a strong association with UA, are met
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Strengths of the study include our a priori hypotheses based on our previous studies, and while it is a small clinical sample, we replicated our findings of the predictive utility of PBMC TL for the primary outcome of depressive symptoms
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