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For patients taking other medications that affect heart rate, such as beta-blockers, non-dihydropyridine calcium channel blockers (verapamil, diltiazem), or stimulants, careful medication review and potential adjustments may be necessary

During the resolution of inflammation, SPMs produced by polymorphonuclear cells and macrophages act to limit local tissue damage caused by inflammatory responses, including signaling cessation of polymorphonuclear cell infiltration, macrophage switching to an anti-inflammatory phenotype, apoptotic cell clearance, and reducing pain caused by nociceptor sensitization (49, 61)

What Studies Show In a Phase 2 clinical trial published in The Lancet Diabetes & Endocrinology , patients taking survodutide experienced meaningful, dose-dependent weight loss

This is clinically insignificant