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Small-molecule pan-ERR agonists extend this paradigm by directly potentiating receptor activity, enabling controlled experimental induction of the exercise program in sedentary animals

Under these conditions, FOXO4 phosphorylation and binding to p53 occurs

A large-scale study showed improvements in the ADAS-cog+ assessment, with treated subjects improving by 10.62 points compared to 4.4 points in control groups, representing a significant difference of 6.2 points

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