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Importantly, in our previous study, hypoxia-preconditioned USC-seeded tissue engineered constructs developed to enhance wound healing did not exhibit tumorigenic behavior following implantation in vivo (Zhang et al., 2020)

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NOX is a membrane-bound enzyme complex that faces the extracellular space, and it can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms