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The subsequent FDA approvals of Wegovy and Zepbound for weight management further solidified what had already become common prescribing behavior across various medical specialties
In the case of semaglutide, it's posited that the medication's effectiveness in reducing appetite and promoting weight loss could inadvertently lead to amenorrhea
The closest performing GLP-1 medicine in terms of average weight loss is Novo Nordisks CagriSema, an Amylin/GLP-1 dual agonist, which had an average weight loss of 22.7% after 68 weeks in Phase 3 trials
2015;5(12):e007568
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