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By reducing tyrosinase activity, glutathione can help prevent the formation of excess melanin, resulting in a brighter and more even complexion

While previous reviews have addressed micronutrient roles in thyroid dysfunction or cardiovascular risk independently, this review offers a novel integrative approach by linking nutrient status, sex-specific effects, and autoimmune mechanisms into a unified framework

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Together, these mechanisms underpin the scientific rationale for using glutathione in modern skin brightening products, making it a valuable active for serums, essences, creams, and ampoules that focus on safe, gradual, and multidimensional brightening effects