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However, the VEGF family and its receptors, including VEGFR, have been found to be expressed in about half of the human cancers studied, such as ovarian cancer, melanoma, thyroid cancer, and more [111,112,113,114]

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AGEs, the formation of which is promoted by high blood sugar levels, are compounds formed when sugars chemically modify proteins, lipids, and nucleic acids (Forbes 2003

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