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A phase I-II study of high-dose thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic marrow transplantation

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PEGylation the covalent attachment of polyethylene glycol (PEG) chains via a succinyl linker surrounds the peptide with a steric hydrophilic shield that dramatically increases hydrodynamic radius, reduces renal filtration, and provides protection from proteolytic degradation