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Under physiological conditions, KEAP1 mediates NRF2s constitutive proteasomal degradation (McMahon et al., 2003) while BACH1 acts as transcriptional antagonist of NRF2s target genes (Zhang and Hannink, 2003)

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FSP1-mediated reduction of vitamin Kexpanding substrate scope Although CoQ 10 is the primary known substrate of FSP1, emerging evidence indicates that FSP1 exhibits promiscuous substrate specificity