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Interestingly, this raises important points in regard to the need to hold GLP-1 RAs prior to concurrent EGD and colonoscopy procedures and the number of days needed to hold these agents, if necessary

FDA labels for GLP-1 receptor agonists include warnings about increased risk of acute gallbladder disease, including cholecystitis and cholelithiasis, based on clinical trials and post-marketing data

Trials to date have focused on weight and metabolic outcomes, with lean mass reduction typically reported as a secondary endpoint and without standardized functional measures

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