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Other monitored potential side effects include Nausea Vomiting Diarrhea Constipation Decreased appetite Transient increases in heart rate Gallbladder-related events (e.g., cholelithiasis) Elevated pancreatic enzymes These side effects typically diminish over time with continued treatment and appropriate dose titration

Those with gastrointestinal tract problems who cannot absorb vitamin B12 properly

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NAD+ is a critical coenzyme involved in hundreds of enzymatic reactions including glycolysis, the citric acid cycle, and oxidative phosphorylation, as well as serving as a substrate for NAD+-consuming enzymes including sirtuins, PARPs, and CD38