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Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37

Similar results were obtained with a transcriptomic analysis following the pollution-caused CFTR decrease in 16HBE14o-cells

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