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Some of these biological drivers that accelerate cellular aging include: Mitochondrial dysfunction (your cells ability to produce energy efficiently) DNA damage (which accumulates over time and affects cell function) Cellular senescence ( old or damaged cells that stop dividing but dont die off) Oxidative stress (an imbalance between free radicals and your antioxidant defenses) Chronic inflammation (low-grade inflammation that disrupts repair and immunity) Impaired tissue repair (a reduced ability to regenerate and heal) Hormonal changes (declines in key hormones that regulate metabolism, cognition, and more) Immune system decline (reduced ability to defend against threats and remove cellular waste) These internal biological mechanisms form a feedback loop that accelerates aging from the inside out
The polybasic amino acids (residue 392398, KRTKRKK) of Sirt7 are also essential for Sirt7 localization in nucleolus, where ribosomal RNAs are enriched 38
Conceived hypotheses, designed experiments, wrote, and edited the manuscript: CB, MF, and JC
