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On the other hand, the gene expression of mitochondrial biogenesis markers ( PGC1 , AMPK , SIRT1 , NRF2 , and MFN2 ) and mitochondrial activity marker ( COXIV ) in liver-specific GHRKO (LiGHRKO) and wild-type mice are significantly different between the males and females, suggesting that sexual dimorphism may also play an essential role in regulating the mitochondrial biogenesis (Zawada et al., 2015)

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For instance, food deserts, where grocery stores are scarce and fast food is more accessible, disproportionately affect low-income and Black communities, contributing to higher rates of obesity and diabetes