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In contrast, only 3 extracellular metabolites, 2-isopropylmalate, 4-aminobenzoate, and glutamate, showed significant differences between wild-type and gdh3 / gdh3 strains cultured on arginine medium

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17 This is not surprising as microvascular functions are dependent on a normal metabolic milieu, which is disturbed in the state of insulin resistance as seen in obesity and T2DM, including elevated plasma free fatty acids and inflammatory cytokines