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Melasma is treatable, not curable

PI3K generates the lipid second messenger PIP3, which activates Akt

The therapeutic potential of VD-mediated GMBA modulation requires cautious interpretation, due to lack of VD status monitoring in donor/recipient animals and the absence of microbial metabolite profiling

848 Resveratrol may improve I/R injury by activating SIRT3/FOXO3a pathway, which increases the expression of catalase and SOD2 and inhibits the production of ROS, thereby reducing lipid peroxidation and ferroptosis