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Risk of developing each substance use disorder also declined significantly by 18% for alcohol, 14% for cannabis, 20% for cocaine and nicotine, and 25% for opioids

The second cohort included patients with a diagnosis of polycystic ovary syndrome (PCOS) recorded during or before the study period

It is proposed that this non-invasive risk score be used in a primary care clinic and non-hepatology settings to identify individuals at high risk of advanced liver disease with FIB-4 scores greater than 2.67 and refer them to hepatology